10301
ANTIBODY DEPENDENT ENHANCEMENT
Image Source: www.freepik.com
News regarding the readiness of the Indonesian government to immediately start the COVID-19 vaccination process for the wider community was welcomed by various groups. How could it not, it has been almost a year since the Indonesian people and people around the world have had to make major adjustments and restrictions on their lifestyle and activities that they have been doing. The COVID-19 pandemic has not only caused a negative impact on public health, but has also dragged various other aspects of life - such as financial and social - into a downturn. So it is not surprising that even the slightest good news will be welcomed happily by the public.
In previous articles, we have discussed the process of producing and testing vaccines, as well as vaccine candidates that are the target of the Indonesian government. In this article, we will discuss a phenomenon that has recently become a byword in the community, because it is one of the potential concerns of giving the COVID-19 vaccine.
The phenomenon we are going to talk about is called Antibody-Dependent Enhancement (ADE). If we look at the definition literally, this phenomenon is a condition in which there is an increase or acceleration of certain activities caused by the presence of an antibody. Unfortunately, the increase in this phenomenon is not a good thing and we want. What actually happens is an increase in the severity of a disease, which occurs as a result of the presence of certain antibodies in the body.
How can this phenomenon occur?
In the ADE phenomenon, vaccine administration will indeed form an antibody. However, these antibodies will not help our bodies fight infection, they will actually help viruses that enter the body more easily infect our bodies. With ADE, an infected body that has previously received vaccinations will have the potential to experience a more severe degree of disease.
The ADE condition is of course not just a theory. The potential for ADE itself has indeed appeared in the dengue haemorrhagic fever (DHF) vaccine. In 1977, Scott Halstead, a virologist at the University of Hawaii, noticed the unexpected, unknown phenomenon of dengue fever. Animals that have produced antibodies to one of the four strains of dengue fever virus got more sick when they were exposed to the disease the second time. It is thought that the cause is that the antibodies produced during the first exposure give the second virus a chance to enter the body.
Apart from the dengue vaccine, the ADE phenomenon has also appeared in the research of SARS, MERS, Ebola, RSV, and HIV vaccines in silico (computer simulation) and in vitro (experiments in laboratory petri dishes). In humans, the phenomenon of ADE in these vaccines cannot be proven because there is no adequate, long, and extensive research.
Although ADE is indeed a serious problem, there has been no evidence or reports of ADE in any clinical trials of the COVID-19 vaccine. Professor of UNPAD Faculty of Medicine who is also the Chair of the UNPAD COVID-19 Vaccine Research Team, Prof. Dr. Kusnandi Rusmil, dr., Sp.A (K), M.M. emphasized that until now, the phenomenon of ADE that is of concern has not appeared in any clinical trials of the COVID-19 vaccine. However, this is not a reason for us to be careless, as vigilance and monitoring of vaccine safety are a priority in the clinical trial process. In particular, taking into account that the vaccine manufacturing process is much shorter when compared to the manufacturing process of vaccines in general.
We all agree, of course, that we want a vaccine for COVID-19 to be found as soon as possible, so that we can 'return' to our pre-COVID-19 life. However, it must be said that a vaccine, whose safety and efficacy have not been tested, could be worse than the absence of a vaccine. We certainly do not want to receive a vaccine that has not been tested for safety and efficacy. We don't want our society to have a "false sense of security", triggered by the assumption that they "feel immune" from COVID-19, which tends to let people down and ignore health protocols. Because in fact, the vaccination we can most rely on at this time is to remain consistent and patient to carry out proper and correct health protocols.
Author
dr. Laras Prabandini Sasongko, AAAIJ
Email: laras@indonesiare.co.id
Artikel
- InsurTech: A Growing Synergy Between Insurance, Technology, and Healthcare
13 Sep 2024
969 kali - Sepak Terjang Streptococcal Toxic Shock Syndrome (STSS)09 Jul 20241277 kali
- Pengaruh Penggunaan Proton Pump Inhibitor terhadap Gangguan Kandung Empedu27 Jun 20241377 kali
- Mengenal ‘Disease X’, The Future Next Pandemic?06 May 20241692 kali
- Vertigo dan Meniere’s Disease02 Apr 20241767 kali
- Potensi dan Langkah Mitigasi Bahaya Rokok Elektrik07 Feb 20241492 kali
- Kebangkitan Infeksi Polio di Indonesia23 Jan 20241483 kali
- Mengenal COVID-19 Varian JN.122 Dec 20233987 kali
- Lonjakan Kasus COVID-19 di Akhir Tahun 202320 Dec 20233958 kali
- Potret Wabah ‘Pneumonia Misterius’ di Indonesia dan Dunia07 Dec 20234530 kali
- Infeksi HPV, Kanker Cervix, dan Metode Pencegahannya04 Dec 20234348 kali
- Perspektif Kepemilikan Asuransi Penyakit Kritis bagi Kelompok Usia Muda21 Nov 20234433 kali
- Kemunculan Kasus Mpox Kedua: Apakah Berpotensi Menjadi Epidemi Baru di Indonesia?30 Oct 20233673 kali
- Underweight dan Bahaya Kesehatan di Baliknya10 Oct 20233818 kali
- Penggunaan Air Purifier: Apakah Merupakan Solusi Efektif untuk Mengatasi Gangguan Pernapasan akibat Kualitas Udara Buruk?03 Oct 20233293 kali
- Fenomena Peningkatan Insidensi HIV/AIDS pada Ibu Rumah Tangga12 Jun 20239782 kali
- Marburg Virus Disease24 May 20236265 kali
- Sudden Sensorineural Hearing Loss26 Apr 20239262 kali
- Tuberculosis pada Anak10 Apr 202310024 kali
- Flu Burung Clade 2.3.4.4b28 Mar 202311077 kali
- Penerapan Sustainable Development Goals (SDGs) dalam Operasional Industri Perasuransian Nasional20 Feb 202315857 kali
- Memahami Fenomena Bonus Demografi dan Pengaruhnya pada Industri Asuransi Jiwa26 Jan 202319760 kali
- Vaksin Inavac12 Jan 202316380 kali
- Stroke Batang Otak06 Jan 202319634 kali
- Ada Apa dengan China?28 Dec 202211837 kali
- Gonorrhea Superbug21 Dec 202211668 kali
- Crimean-Congo Hemorrhagic Fever14 Dec 20226653 kali
- Vaksin IndoVac29 Nov 20225977 kali
- Cedera Sambaran Petir24 Nov 20224857 kali
- Emboli Paru dan Tragedi Perayaan Halloween di Itaewon11 Nov 20224709 kali
- Covid Subvarian XBB dan XBC03 Nov 20223991 kali
- Fenomena Resistensi Antibiotik dan Infeksi Superbug26 Oct 20224747 kali
- Telaah Fenomena Gagal Ginjal Akut pada Anak18 Oct 20225939 kali
- Penggunaan Kendaraan Listrik dari Perspektif Kesehatan dan Lingkungan04 Oct 20228871 kali
- Zero Covid Policy22 Sep 20225477 kali
- Fenomena Antibody Dependent Enhancement (ADE) pada Sistem Imun31 Aug 20225644 kali
- Mengenal Batuk Berdarah22 Aug 20228997 kali
- Mengenal Virus Langya dan Potensi Emerging Disease12 Aug 20222585 kali
- Long Covid dalam Perspektif Asuransi Jiwa dan Kesehatan05 Aug 20222880 kali
- Covid Centaurus26 Jul 20222874 kali
- Menyikapi Penghapusan Ketentuan Waiting Period pada SEOJK PAYDI11 Jul 20224693 kali
- Telaah Ganja Medis sebagai Alternatif Pengobatan07 Jul 20224236 kali
- Ada Apa dengan BA.4 dan BA.5?24 Jun 20222389 kali
- Ramsay-Hunt Syndrome20 Jun 20222806 kali
- Keterkaitan Asma dengan GERD10 Jun 20224840 kali
- Penyakit Virus Hendra03 Jun 20222954 kali
- Mengenal Cacar Monyet26 May 20222435 kali
- Keterkaitan Infeksi Covid dengan Hepatitis Misterius19 May 20222594 kali
- Hepatitis Misterius19 May 20222652 kali
- Serba-Serbi Sakit Pinggang11 May 20224973 kali
- Evidence Based Medicine22 Apr 202217827 kali
- Mewaspadai Potensi Penyakit Ginjal pada Penyintas Covid07 Apr 20223084 kali
- Penyakit Tipes, Penyakit Masyarakat Indonesia31 Mar 20225151 kali
- Menilik Kesiapan Indonesia vs Negara Tetangga Dalam Melangkah Ke Status Endemi29 Mar 20222672 kali
- Riwayat Pandemi Flu Spanyol 191816 Mar 20227563 kali
- Son of Omricon09 Mar 20222568 kali
- Vaksin Zifivax22 Feb 20226772 kali
- Bahaya Strobo Bagi Kesehatan15 Feb 20223762 kali
- Flurona, Infeksi Apakah Itu?02 Feb 20222415 kali
- Pentingnya Warna Urine Sebagai Indikator Kesehatan25 Jan 202234632 kali
- Spinal Cord Injury17 Jan 202212237 kali
- Mengenal Gerd03 Jan 20225843 kali
- Tentang Varian Omicron10 Dec 20213198 kali
- Mengenal Nyeri Dada06 Dec 20214610 kali
- Mengenal Insomnia dan Sleep Deprivation29 Nov 202113334 kali
- Mental Health Awareness Di Lingkungan Kerja23 Nov 20218103 kali
- Dampak Kemunculan Virus Covid Subvarian Delta Plus12 Nov 20213047 kali
- Pemberian Vaksin Pfizer Pada Anak29 Oct 20213764 kali
- Risiko Myokarditis Pada Penerima Vaksin MRNA19 Oct 20217177 kali
- Pengajuan Asuransi Jiwa dan Kesehatan Bagi Penyintas Covid06 Oct 20212768 kali
- Tentang Varian MU28 Sep 20213093 kali
- Tentang Vaksin Sputnik-V15 Sep 20214136 kali
- Badai Sitokin pada Penderita Covid01 Sep 20219610 kali
- Vaksin Moderna Di Indonesia25 Aug 20215969 kali
- Amunisi Pandemi Anak Bangsa09 Aug 20213397 kali
- Pemberian Dosis Booster pada Program Vaksinasi Covid di Indonesia05 Aug 20213865 kali
- Telaah Penggunaan Azithromycin dalam Pengobatan COVID-1928 Jul 202110663 kali
- Peranan Vitamin D dalam Imunitas23 Jul 20217319 kali
- Polemik Ivermectin dalam Pengobatan COVID-1914 Jul 20214411 kali
- Peningkatan Kasus COVID-19 pada Anak di Indonesia28 Jun 20213336 kali
- Peranan Varian Mutasi dalam Lonjakan Kasus COVID-19 di Indonesia18 Jun 20213335 kali
- Wacana Sekolah Tatap Muka di Tengah Pandemi COVID-1914 Jun 20218324 kali
- Infeksi Jamur Hitam pada Penderita COVID-1910 Jun 20214564 kali
- Program Vaksinasi Gotong Royong09 Jun 20213798 kali
- Faedah Pemberian Terapi Plasma Konvalesen bagi Penderita COVID-1904 Jun 20214460 kali
- Fenomena Long Covid pada Penyintas18 May 20216000 kali
- Mengenal Varian P1 dari SARS-CoV-230 Apr 20213770 kali
- Vaksin COVID-19 untuk Ibu Hamil19 Apr 20213921 kali
- Mengenal Varian Trégor16 Apr 20212983 kali
- Multisystem Inflammatory Syndrome In Children (Mis-C)24 Mar 202113448 kali
- Polemik Vaksin Astrazeneca19 Mar 20215903 kali
- Tentang Varian Mutasi B 117 Yang hadir di Indonesia15 Mar 20213026 kali
- Pengembangan Vaksin Covid-19 Di Indonesia26 Feb 20214943 kali
- Rekomendasi Terbaru Kemenkes Untuk Vaksinasi Covid-1918 Feb 20215353 kali
- Proses Pengelolaan Masker Medis Bekas Pakai15 Feb 20214203 kali
- Pandemic Fatigue11 Feb 20213186 kali
- TELAAH IMUNITAS DALAM DISIPLIN ILMU PSIKONEUROIMUNOLOGI01 Feb 20216889 kali
- Fakta-Fakta Terkait Kejadian Kematian Penerima Vaksin Pfizer22 Jan 20214351 kali
- Kesiapan Edar Vaksin Sinovac di Indonesia15 Jan 20214146 kali
- ISOLASI MANDIRI PADA COVID-1908 Jan 20214237 kali
- Mengenal Mutasi VUI-202012/0104 Jan 20213146 kali
- Delirium pada Penderita COVID-1923 Dec 20206102 kali
- Wacana Dimulainya Penyelenggaraan Sekolah Tatap Muka Kembali23 Dec 20203335 kali
- Gangguan Pencernaan Pada Kasus Covid-1922 Dec 20206499 kali
- Potensi Terjadinya Cross-Reactive-Immunity Terhadap Individu Yang Belum Terekspos Sars-Cov-221 Dec 20204197 kali
- Get to Know The Pfizer Vaccine27 Nov 20207760 kali
- Chloroquine in Covid-19 Treatment20 Nov 20204463 kali
- Domination of Office Clusters on The COVID-19 Pandemic20 Nov 20203524 kali
- In-Flight Risks of Covid-19 Transmission17 Nov 20203301 kali
- About The Herd Immunity24 Jul 20204276 kali
- Could COVID-19 occur in animals?20 Jul 20203724 kali
- Virus Flu Babi G4 EA H1N1, Akankan Menjadi Pandemi Baru Di Tahun Ini ?03 Jul 20204619 kali
- Penggunaan Masker Dalam Kehidupan ‘Normal Baru’26 Jun 20203860 kali
- A Flashback of Handling COVID-19 in Indonesia28 May 20203167 kali
- COVID-19 dan Penyakit Kardiovaskular11 May 20203728 kali
- Proses Pembuatan Vaksin05 May 202078988 kali
- COVID-19 dan Demam Dengue28 Apr 20203977 kali
- Mitos dan Fakta tentang COVID-1923 Mar 20203923 kali
- Menangani Gigitan Ular02 Mar 20207506 kali
- Mengenal GERD24 Feb 20207640 kali
- Serba-Serbi Jamu17 Feb 20204161 kali
- Mengoptimalkan Kekebalan Tubuh10 Feb 20203081 kali
- 2019 - Novel Coronavirus28 Jan 20204024 kali
- Vegan vs Vegetarian20 Jan 20204594 kali
- Banjir, Penyakit Pes, dan Leptospirosis13 Jan 202010221 kali
- Serba-Serbi Vitamin D06 Jan 20203370 kali
- Hyperventilation Syndrome30 Dec 201924145 kali
- Pentingnya Kalsium untuk Tubuh26 Dec 20197850 kali
- Serba-Serbi Keluarga Berencana17 Dec 20197024 kali
- Chronic Fatigue Syndrome09 Dec 20198483 kali
- Hipnosis dan Diet Hipnoterapi03 Dec 20197226 kali
- Manfaat Ikan Salmon25 Nov 20198142 kali
- Ulkus Lambung18 Nov 201916392 kali
- Sifilis12 Nov 201921068 kali
- Mengkonsumsi Vitamin C05 Nov 20196876 kali
- Skizofrenia28 Oct 20198330 kali
- Overdosis Kafein21 Oct 20193427 kali
- Bahaya Mengkonsumsi Makanan dan Minuman Panas16 Oct 201916393 kali
- Peran Kolesterol bagi Kesehatan Tubuh27 Aug 20198367 kali
- Penyebab Bau Badan14 Aug 20195192 kali
- Social Drinker05 Aug 201917646 kali
- Mengenal Kandung Empedu30 Jul 201959339 kali
- Nutrisi untuk Rambut15 Jul 20193056 kali
- Mengenal Rambut08 Jul 201947913 kali
- Apakah Menguap Itu Selalu Pertanda Mengantuk01 Jul 20198477 kali
- Serba Serbi Warna Ingus28 Jun 201923589 kali
- Mengenal Cacar Monyet21 May 20194990 kali
- Manfaat Berpuasa bagi Kesehatan06 May 20193223 kali
- Mengapa Garam Dapat Menyebabkan Tekanan Darah Meningkat?29 Apr 201928756 kali
- Mengapa Kita Mengalami Cegukan?22 Apr 201911982 kali
- Manfaat Bawang Putih15 Apr 20198987 kali
- Mau tidur siang? Ternyata ada aturannya, lho!26 Mar 20198792 kali
- Extrapulmonary Tuberculosis18 Mar 201911837 kali
- Manfaat Zat Besi untuk Tubuh14 Mar 20197976 kali
- Hipertensi pada Anak06 Mar 201927794 kali
- Gangguan Psikosomatis04 Mar 201911633 kali
- Pentingnya Tidur Untuk Kesehatan18 Feb 20198338 kali
- Waspada Demam Berdarah Dengue (DBD)!12 Feb 20199423 kali
- Fungsi Usus Buntu04 Feb 201917152 kali
- Serba-serbi Tonsil28 Jan 201934578 kali
- Protein dan Asam Amino21 Jan 201982814 kali
- Mengenal IQOS14 Jan 201937290 kali
- Mengenal Diet Keto07 Jan 20199314 kali
- Serba-Serbi Kurang Tidur31 Dec 20185196 kali
- Kolesterol yang Terlalu Rendah26 Dec 20183980 kali
- Ada Apa dengan Nasi?26 Dec 20185090 kali
- Benarkah Vape Tidak Berbahaya?11 Dec 20186980 kali
- Efusi Pleura12 Nov 201820377 kali
- Pneumonia06 Nov 20188919 kali
- Encephalitis29 Oct 20187199 kali
- Meningitis22 Oct 20189379 kali
- Imunisasi Rotavirus15 Oct 201815710 kali
- Prostatitis11 Jul 20188342 kali
- Cystitis02 Jul 201815411 kali
- Tahan Banting Selama Puasa04 Jun 20184154 kali
- Vaksin untuk anak : Iya atau Tidak?21 May 20184044 kali
- Vaksin Cacar Air, Penting atau Tidak ?30 Apr 201816156 kali
- Eclampsia23 Apr 20184866 kali
- Chikungunya12 Mar 201813046 kali
- Rubeola05 Mar 201813065 kali
- Benign Prostatic Hyperplasia05 Feb 20189172 kali
- Transplantasi Liver06 Mar 20177962 kali
- Diet sehat itu seperti apa?06 Mar 20175419 kali
- Sirosis Hati06 Mar 201718489 kali
- Pre-Diabetes, akankah menjadi Diabetes?06 Mar 201710498 kali
- Pancreatic Cancer03 Mar 20178104 kali
- Kanker Lambung03 Mar 201711384 kali
- HFMD02 Mar 20179977 kali
- Cholelithiasis02 Mar 201763691 kali
- Alcohol-Related Liver Disease02 Mar 20176737 kali
- Rokok Elektronik: Penolong dari Ketergantungan atau Alternatif Baru Merokok?10 Dec 20166851 kali
Follow Us
