10926
ANTIBODY DEPENDENT ENHANCEMENT
Image Source: www.freepik.com
News regarding the readiness of the Indonesian government to immediately start the COVID-19 vaccination process for the wider community was welcomed by various groups. How could it not, it has been almost a year since the Indonesian people and people around the world have had to make major adjustments and restrictions on their lifestyle and activities that they have been doing. The COVID-19 pandemic has not only caused a negative impact on public health, but has also dragged various other aspects of life - such as financial and social - into a downturn. So it is not surprising that even the slightest good news will be welcomed happily by the public.
In previous articles, we have discussed the process of producing and testing vaccines, as well as vaccine candidates that are the target of the Indonesian government. In this article, we will discuss a phenomenon that has recently become a byword in the community, because it is one of the potential concerns of giving the COVID-19 vaccine.
The phenomenon we are going to talk about is called Antibody-Dependent Enhancement (ADE). If we look at the definition literally, this phenomenon is a condition in which there is an increase or acceleration of certain activities caused by the presence of an antibody. Unfortunately, the increase in this phenomenon is not a good thing and we want. What actually happens is an increase in the severity of a disease, which occurs as a result of the presence of certain antibodies in the body.
How can this phenomenon occur?
In the ADE phenomenon, vaccine administration will indeed form an antibody. However, these antibodies will not help our bodies fight infection, they will actually help viruses that enter the body more easily infect our bodies. With ADE, an infected body that has previously received vaccinations will have the potential to experience a more severe degree of disease.
The ADE condition is of course not just a theory. The potential for ADE itself has indeed appeared in the dengue haemorrhagic fever (DHF) vaccine. In 1977, Scott Halstead, a virologist at the University of Hawaii, noticed the unexpected, unknown phenomenon of dengue fever. Animals that have produced antibodies to one of the four strains of dengue fever virus got more sick when they were exposed to the disease the second time. It is thought that the cause is that the antibodies produced during the first exposure give the second virus a chance to enter the body.
Apart from the dengue vaccine, the ADE phenomenon has also appeared in the research of SARS, MERS, Ebola, RSV, and HIV vaccines in silico (computer simulation) and in vitro (experiments in laboratory petri dishes). In humans, the phenomenon of ADE in these vaccines cannot be proven because there is no adequate, long, and extensive research.
Although ADE is indeed a serious problem, there has been no evidence or reports of ADE in any clinical trials of the COVID-19 vaccine. Professor of UNPAD Faculty of Medicine who is also the Chair of the UNPAD COVID-19 Vaccine Research Team, Prof. Dr. Kusnandi Rusmil, dr., Sp.A (K), M.M. emphasized that until now, the phenomenon of ADE that is of concern has not appeared in any clinical trials of the COVID-19 vaccine. However, this is not a reason for us to be careless, as vigilance and monitoring of vaccine safety are a priority in the clinical trial process. In particular, taking into account that the vaccine manufacturing process is much shorter when compared to the manufacturing process of vaccines in general.
We all agree, of course, that we want a vaccine for COVID-19 to be found as soon as possible, so that we can 'return' to our pre-COVID-19 life. However, it must be said that a vaccine, whose safety and efficacy have not been tested, could be worse than the absence of a vaccine. We certainly do not want to receive a vaccine that has not been tested for safety and efficacy. We don't want our society to have a "false sense of security", triggered by the assumption that they "feel immune" from COVID-19, which tends to let people down and ignore health protocols. Because in fact, the vaccination we can most rely on at this time is to remain consistent and patient to carry out proper and correct health protocols.
Author
dr. Laras Prabandini Sasongko, AAAIJ
Email: laras@indonesiare.co.id
Artikel
- InsurTech: A Growing Synergy Between Insurance, Technology, and Healthcare
13 Sep 2024
1749 kali - Sepak Terjang Streptococcal Toxic Shock Syndrome (STSS)09 Jul 20241672 kali
- Pengaruh Penggunaan Proton Pump Inhibitor terhadap Gangguan Kandung Empedu27 Jun 20242121 kali
- Mengenal ‘Disease X’, The Future Next Pandemic?06 May 20242398 kali
- Vertigo dan Meniere’s Disease02 Apr 20242146 kali
- Potensi dan Langkah Mitigasi Bahaya Rokok Elektrik07 Feb 20242086 kali
- Kebangkitan Infeksi Polio di Indonesia23 Jan 20242118 kali
- Mengenal COVID-19 Varian JN.122 Dec 20234572 kali
- Lonjakan Kasus COVID-19 di Akhir Tahun 202320 Dec 20234520 kali
- Potret Wabah ‘Pneumonia Misterius’ di Indonesia dan Dunia07 Dec 20234875 kali
- Infeksi HPV, Kanker Cervix, dan Metode Pencegahannya04 Dec 20234910 kali
- Perspektif Kepemilikan Asuransi Penyakit Kritis bagi Kelompok Usia Muda21 Nov 20234788 kali
- Kemunculan Kasus Mpox Kedua: Apakah Berpotensi Menjadi Epidemi Baru di Indonesia?30 Oct 20234272 kali
- Underweight dan Bahaya Kesehatan di Baliknya10 Oct 20234125 kali
- Penggunaan Air Purifier: Apakah Merupakan Solusi Efektif untuk Mengatasi Gangguan Pernapasan akibat Kualitas Udara Buruk?03 Oct 20233961 kali
- Fenomena Peningkatan Insidensi HIV/AIDS pada Ibu Rumah Tangga12 Jun 202310362 kali
- Marburg Virus Disease24 May 20236851 kali
- Sudden Sensorineural Hearing Loss26 Apr 20239423 kali
- Tuberculosis pada Anak10 Apr 202310169 kali
- Flu Burung Clade 2.3.4.4b28 Mar 202311638 kali
- Penerapan Sustainable Development Goals (SDGs) dalam Operasional Industri Perasuransian Nasional20 Feb 202316536 kali
- Memahami Fenomena Bonus Demografi dan Pengaruhnya pada Industri Asuransi Jiwa26 Jan 202320842 kali
- Vaksin Inavac12 Jan 202316516 kali
- Stroke Batang Otak06 Jan 202319923 kali
- Ada Apa dengan China?28 Dec 202212378 kali
- Gonorrhea Superbug21 Dec 202212233 kali
- Crimean-Congo Hemorrhagic Fever14 Dec 20227315 kali
- Vaksin IndoVac29 Nov 20226083 kali
- Cedera Sambaran Petir24 Nov 20225483 kali
- Emboli Paru dan Tragedi Perayaan Halloween di Itaewon11 Nov 20225259 kali
- Covid Subvarian XBB dan XBC03 Nov 20224550 kali
- Fenomena Resistensi Antibiotik dan Infeksi Superbug26 Oct 20225415 kali
- Telaah Fenomena Gagal Ginjal Akut pada Anak18 Oct 20226055 kali
- Penggunaan Kendaraan Listrik dari Perspektif Kesehatan dan Lingkungan04 Oct 20229783 kali
- Zero Covid Policy22 Sep 20225584 kali
- Fenomena Antibody Dependent Enhancement (ADE) pada Sistem Imun31 Aug 20226496 kali
- Mengenal Batuk Berdarah22 Aug 20229662 kali
- Mengenal Virus Langya dan Potensi Emerging Disease12 Aug 20223140 kali
- Long Covid dalam Perspektif Asuransi Jiwa dan Kesehatan05 Aug 20223442 kali
- Covid Centaurus26 Jul 20223441 kali
- Menyikapi Penghapusan Ketentuan Waiting Period pada SEOJK PAYDI11 Jul 20225257 kali
- Telaah Ganja Medis sebagai Alternatif Pengobatan07 Jul 20224392 kali
- Ada Apa dengan BA.4 dan BA.5?24 Jun 20222937 kali
- Ramsay-Hunt Syndrome20 Jun 20223131 kali
- Keterkaitan Asma dengan GERD10 Jun 20225419 kali
- Penyakit Virus Hendra03 Jun 20223529 kali
- Mengenal Cacar Monyet26 May 20222996 kali
- Keterkaitan Infeksi Covid dengan Hepatitis Misterius19 May 20223139 kali
- Hepatitis Misterius19 May 20223204 kali
- Serba-Serbi Sakit Pinggang11 May 20225111 kali
- Evidence Based Medicine22 Apr 202218627 kali
- Mewaspadai Potensi Penyakit Ginjal pada Penyintas Covid07 Apr 20223659 kali
- Penyakit Tipes, Penyakit Masyarakat Indonesia31 Mar 20225768 kali
- Menilik Kesiapan Indonesia vs Negara Tetangga Dalam Melangkah Ke Status Endemi29 Mar 20223224 kali
- Riwayat Pandemi Flu Spanyol 191816 Mar 20228019 kali
- Son of Omricon09 Mar 20222654 kali
- Vaksin Zifivax22 Feb 20226897 kali
- Bahaya Strobo Bagi Kesehatan15 Feb 20226125 kali
- Flurona, Infeksi Apakah Itu?02 Feb 20222957 kali
- Pentingnya Warna Urine Sebagai Indikator Kesehatan25 Jan 202235376 kali
- Spinal Cord Injury17 Jan 202212490 kali
- Mengenal Gerd03 Jan 20226541 kali
- Tentang Varian Omicron10 Dec 20213283 kali
- Mengenal Nyeri Dada06 Dec 20215183 kali
- Mengenal Insomnia dan Sleep Deprivation29 Nov 202114320 kali
- Mental Health Awareness Di Lingkungan Kerja23 Nov 20218704 kali
- Dampak Kemunculan Virus Covid Subvarian Delta Plus12 Nov 20213599 kali
- Pemberian Vaksin Pfizer Pada Anak29 Oct 20214310 kali
- Risiko Myokarditis Pada Penerima Vaksin MRNA19 Oct 20217554 kali
- Pengajuan Asuransi Jiwa dan Kesehatan Bagi Penyintas Covid06 Oct 20213310 kali
- Tentang Varian MU28 Sep 20213221 kali
- Tentang Vaksin Sputnik-V15 Sep 20214264 kali
- Badai Sitokin pada Penderita Covid01 Sep 202110297 kali
- Vaksin Moderna Di Indonesia25 Aug 20216087 kali
- Amunisi Pandemi Anak Bangsa09 Aug 20213935 kali
- Pemberian Dosis Booster pada Program Vaksinasi Covid di Indonesia05 Aug 20214411 kali
- Telaah Penggunaan Azithromycin dalam Pengobatan COVID-1928 Jul 202110777 kali
- Peranan Vitamin D dalam Imunitas23 Jul 20217688 kali
- Polemik Ivermectin dalam Pengobatan COVID-1914 Jul 20214739 kali
- Peningkatan Kasus COVID-19 pada Anak di Indonesia28 Jun 20213869 kali
- Peranan Varian Mutasi dalam Lonjakan Kasus COVID-19 di Indonesia18 Jun 20213902 kali
- Wacana Sekolah Tatap Muka di Tengah Pandemi COVID-1914 Jun 20218446 kali
- Infeksi Jamur Hitam pada Penderita COVID-1910 Jun 20215127 kali
- Program Vaksinasi Gotong Royong09 Jun 20214133 kali
- Faedah Pemberian Terapi Plasma Konvalesen bagi Penderita COVID-1904 Jun 20215013 kali
- Fenomena Long Covid pada Penyintas18 May 20216553 kali
- Mengenal Varian P1 dari SARS-CoV-230 Apr 20214331 kali
- Vaksin COVID-19 untuk Ibu Hamil19 Apr 20214014 kali
- Mengenal Varian Trégor16 Apr 20213528 kali
- Multisystem Inflammatory Syndrome In Children (Mis-C)24 Mar 202114063 kali
- Polemik Vaksin Astrazeneca19 Mar 20216258 kali
- Tentang Varian Mutasi B 117 Yang hadir di Indonesia15 Mar 20213117 kali
- Pengembangan Vaksin Covid-19 Di Indonesia26 Feb 20215501 kali
- Rekomendasi Terbaru Kemenkes Untuk Vaksinasi Covid-1918 Feb 20215677 kali
- Proses Pengelolaan Masker Medis Bekas Pakai15 Feb 20214543 kali
- Pandemic Fatigue11 Feb 20213722 kali
- TELAAH IMUNITAS DALAM DISIPLIN ILMU PSIKONEUROIMUNOLOGI01 Feb 20217042 kali
- Fakta-Fakta Terkait Kejadian Kematian Penerima Vaksin Pfizer22 Jan 20214897 kali
- Kesiapan Edar Vaksin Sinovac di Indonesia15 Jan 20214726 kali
- ISOLASI MANDIRI PADA COVID-1908 Jan 20214795 kali
- Mengenal Mutasi VUI-202012/0104 Jan 20213695 kali
- Delirium pada Penderita COVID-1923 Dec 20206662 kali
- Wacana Dimulainya Penyelenggaraan Sekolah Tatap Muka Kembali23 Dec 20203415 kali
- Gangguan Pencernaan Pada Kasus Covid-1922 Dec 20207085 kali
- Potensi Terjadinya Cross-Reactive-Immunity Terhadap Individu Yang Belum Terekspos Sars-Cov-221 Dec 20204559 kali
- Get to Know The Pfizer Vaccine27 Nov 20208346 kali
- Chloroquine in Covid-19 Treatment20 Nov 20205023 kali
- Domination of Office Clusters on The COVID-19 Pandemic20 Nov 20204086 kali
- In-Flight Risks of Covid-19 Transmission17 Nov 20203864 kali
- About The Herd Immunity24 Jul 20204845 kali
- Could COVID-19 occur in animals?20 Jul 20204277 kali
- Virus Flu Babi G4 EA H1N1, Akankan Menjadi Pandemi Baru Di Tahun Ini ?03 Jul 20204743 kali
- Penggunaan Masker Dalam Kehidupan ‘Normal Baru’26 Jun 20204408 kali
- A Flashback of Handling COVID-19 in Indonesia28 May 20203757 kali
- COVID-19 dan Penyakit Kardiovaskular11 May 20204285 kali
- Proses Pembuatan Vaksin05 May 202079872 kali
- COVID-19 dan Demam Dengue28 Apr 20204528 kali
- Mitos dan Fakta tentang COVID-1923 Mar 20204484 kali
- Menangani Gigitan Ular02 Mar 20208113 kali
- Mengenal GERD24 Feb 20208236 kali
- Serba-Serbi Jamu17 Feb 20204254 kali
- Mengoptimalkan Kekebalan Tubuh10 Feb 20203619 kali
- 2019 - Novel Coronavirus28 Jan 20204571 kali
- Vegan vs Vegetarian20 Jan 20204739 kali
- Banjir, Penyakit Pes, dan Leptospirosis13 Jan 202010901 kali
- Serba-Serbi Vitamin D06 Jan 20203468 kali
- Hyperventilation Syndrome30 Dec 201924819 kali
- Pentingnya Kalsium untuk Tubuh26 Dec 20198486 kali
- Serba-Serbi Keluarga Berencana17 Dec 20197139 kali
- Chronic Fatigue Syndrome09 Dec 20199067 kali
- Hipnosis dan Diet Hipnoterapi03 Dec 20197831 kali
- Manfaat Ikan Salmon25 Nov 20198701 kali
- Ulkus Lambung18 Nov 201916661 kali
- Sifilis12 Nov 201921467 kali
- Mengkonsumsi Vitamin C05 Nov 20197453 kali
- Skizofrenia28 Oct 20198516 kali
- Overdosis Kafein21 Oct 20193986 kali
- Bahaya Mengkonsumsi Makanan dan Minuman Panas16 Oct 201917057 kali
- Peran Kolesterol bagi Kesehatan Tubuh27 Aug 20198949 kali
- Penyebab Bau Badan14 Aug 20195814 kali
- Social Drinker05 Aug 201917891 kali
- Mengenal Kandung Empedu30 Jul 201960228 kali
- Nutrisi untuk Rambut15 Jul 20193622 kali
- Mengenal Rambut08 Jul 201948725 kali
- Apakah Menguap Itu Selalu Pertanda Mengantuk01 Jul 20199129 kali
- Serba Serbi Warna Ingus28 Jun 201923941 kali
- Mengenal Cacar Monyet21 May 20195546 kali
- Manfaat Berpuasa bagi Kesehatan06 May 20193772 kali
- Mengapa Garam Dapat Menyebabkan Tekanan Darah Meningkat?29 Apr 201929531 kali
- Mengapa Kita Mengalami Cegukan?22 Apr 201912671 kali
- Manfaat Bawang Putih15 Apr 20199560 kali
- Mau tidur siang? Ternyata ada aturannya, lho!26 Mar 20199424 kali
- Extrapulmonary Tuberculosis18 Mar 201912439 kali
- Manfaat Zat Besi untuk Tubuh14 Mar 20198569 kali
- Hipertensi pada Anak06 Mar 201928630 kali
- Gangguan Psikosomatis04 Mar 201912233 kali
- Pentingnya Tidur Untuk Kesehatan18 Feb 20198951 kali
- Waspada Demam Berdarah Dengue (DBD)!12 Feb 20199566 kali
- Fungsi Usus Buntu04 Feb 201917798 kali
- Serba-serbi Tonsil28 Jan 201934864 kali
- Protein dan Asam Amino21 Jan 201984143 kali
- Mengenal IQOS14 Jan 201938154 kali
- Mengenal Diet Keto07 Jan 20199932 kali
- Serba-Serbi Kurang Tidur31 Dec 20185337 kali
- Kolesterol yang Terlalu Rendah26 Dec 20184521 kali
- Ada Apa dengan Nasi?26 Dec 20185642 kali
- Benarkah Vape Tidak Berbahaya?11 Dec 20187550 kali
- Efusi Pleura12 Nov 201821312 kali
- Pneumonia06 Nov 20189341 kali
- Encephalitis29 Oct 20187786 kali
- Meningitis22 Oct 201810052 kali
- Imunisasi Rotavirus15 Oct 201816312 kali
- Prostatitis11 Jul 20188695 kali
- Cystitis02 Jul 201816088 kali
- Tahan Banting Selama Puasa04 Jun 20184267 kali
- Vaksin untuk anak : Iya atau Tidak?21 May 20184162 kali
- Vaksin Cacar Air, Penting atau Tidak ?30 Apr 201816272 kali
- Eclampsia23 Apr 20185424 kali
- Chikungunya12 Mar 201813785 kali
- Rubeola05 Mar 201813213 kali
- Benign Prostatic Hyperplasia05 Feb 20189804 kali
- Transplantasi Liver06 Mar 20178113 kali
- Diet sehat itu seperti apa?06 Mar 20175958 kali
- Sirosis Hati06 Mar 201718758 kali
- Pre-Diabetes, akankah menjadi Diabetes?06 Mar 201710920 kali
- Pancreatic Cancer03 Mar 20178710 kali
- Kanker Lambung03 Mar 201712021 kali
- HFMD02 Mar 201710581 kali
- Cholelithiasis02 Mar 201764615 kali
- Alcohol-Related Liver Disease02 Mar 20177328 kali
- Rokok Elektronik: Penolong dari Ketergantungan atau Alternatif Baru Merokok?10 Dec 20167013 kali
Follow Us
